Immunological Variation Between Inbred Laboratory Mouse Strains
نویسندگان
چکیده
منابع مشابه
Variation in senescent-dependent lung changes in inbred mouse strains.
Previous studies from our laboratories showed lung development differences between inbred strains of mice. In the present study, the C57BL/6J (B6) and DBA/2J (D2) strains were examined for senescent-dependent differences with respect to the lung structure and function. Specifically, we hypothesize that senescent changes in lung vary between strains due to identifiable gene expression difference...
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Numerous inbred mouse strains comprise models for human diseases and diversity, but the molecular differences between them are mostly unknown. Several mammalian genomes have been assembled, providing a framework for identifying structural variations. To identify variants between inbred mouse strains at a single nucleotide resolution, we aligned 26 million individual sequence traces from four la...
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Excessive systemic exposure to fluoride (F) can lead to disturbances in bone homeostasis and dental enamel development. We have previously shown strain-specific responses to F in the development of dental fluorosis (DF) and in bone formation/mineralization. The current study was undertaken to further investigate F responsive variations in bone metabolism and to determine possible relationships ...
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Inbreeding of mice was begun in 1948 in our labora tories in response to the request of Dr. Franz Bielschow sky, who recognized the need for genetically and nutri tionally uniform animals for cancer research. The resulting strains of inbred NZ mice proved useful for research in immunology, biochemistry, and other fields, and they have been widely distributed. We often have inquiries from invest...
متن کاملIntraocular pressure in inbred mouse strains.
PURPOSE To develop a protocol to measure the intraocular pressure (IOP) of living mice and to determine the IOP of genetically different mouse strains. METHODS Eyes of anesthetized animals were cannulated with a very fine fluid-filled glass microneedle. The microneedle was connected to a pressure transducer, and the pressure signal was analyzed with a computer system. Intraocular pressures of...
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ژورنال
عنوان ژورنال: Veterinary Pathology
سال: 2011
ISSN: 0300-9858,1544-2217
DOI: 10.1177/0300985811429314